KOLs On PAD Innovations And Challenges In 2025

medintel interviewed leading vascular specialists to discuss advances in Peripheral Arterial Disease (PAD) treatments to understand key innovations.

Bioresorbable Scaffolds Show Promise Below the Knee

Following the successful LIFE BTK trial, bioresorbable scaffolds have emerged as potential game-changers for below-knee interventions. This technology addresses both mechanical and biological factors affecting vessel patency. While experts expressed enthusiasm about devices like Abbott's Esprit™ BTK System scaffold, they cautioned about efficacy in longer lesions and suggested potential future applications beyond below-knee territories.

Limus-Based Therapies Gain Momentum

Development of sirolimus-coated balloons has accelerated, particularly for below-knee applications where paclitaxel devices have shown limited efficacy. The SIRONA trial demonstrated non-inferiority of sirolimus versus paclitaxel above the knee at one year. Specialists noted limus-coated devices show reduced distal embolization issues, though technical challenges in drug delivery remain.

Evidence Gap in Vessel Preparation Techniques

Despite widespread use of vessel preparation methods including specialty balloons, lithotripsy, and atherectomy, experts highlighted the lack of robust evidence demonstrating improved outcomes. High-cost devices require stronger proof of clinical benefit, with successful strategies likely needing combination with definitive treatments rather than functioning independently.

ENDS